Applications of Cyclopentadiene for Cancer Treatment
Faculty Mentor
Dr. Ashley Lamm
Presentation Type
Poster
Start Date
5-8-2024 11:15 AM
End Date
5-8-2024 1:00 PM
Location
PUB NCR
Primary Discipline of Presentation
Chemistry and Biochemistry
Abstract
Cyclopentadiene, a five-carbon ring with two double bonds, is reactive in a manner that makes it a valuable tool in cancer research. It’s very effective at forming new bonds between carbon molecules through a Diels–Alder reaction, with no other added reagents, allowing it to be easily and cheaply used in biosynthesis to create new organic molecules. One of the applications of this is the creation of new amino acids, referred to as noncanonical amino acids, which in turn can be used to create antibodies. New drugs can also be made in a similar manner, and the two can be combined to form antibody-drug conjugates (ADCs). ADCs have the precision of antibodies but the effectiveness of drugs, making them extremely deadly to cancer cells while causing less harm to surrounding cells. This paper combines research into both the characteristics of cyclopentadiene that have led to it being selected as the base for these syntheses and how it is being used with great effectiveness and efficiency.
Recommended Citation
Stone, Sarah E., "Applications of Cyclopentadiene for Cancer Treatment" (2024). 2024 Symposium. 35.
https://dc.ewu.edu/srcw_2024/ps_2024/p2_2024/35
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Applications of Cyclopentadiene for Cancer Treatment
PUB NCR
Cyclopentadiene, a five-carbon ring with two double bonds, is reactive in a manner that makes it a valuable tool in cancer research. It’s very effective at forming new bonds between carbon molecules through a Diels–Alder reaction, with no other added reagents, allowing it to be easily and cheaply used in biosynthesis to create new organic molecules. One of the applications of this is the creation of new amino acids, referred to as noncanonical amino acids, which in turn can be used to create antibodies. New drugs can also be made in a similar manner, and the two can be combined to form antibody-drug conjugates (ADCs). ADCs have the precision of antibodies but the effectiveness of drugs, making them extremely deadly to cancer cells while causing less harm to surrounding cells. This paper combines research into both the characteristics of cyclopentadiene that have led to it being selected as the base for these syntheses and how it is being used with great effectiveness and efficiency.
