Role of NtrC in Pseudomonas aeruginosa
Faculty Mentor
Zaara Sarwar
Presentation Type
Poster
Start Date
4-14-2026 9:00 AM
End Date
4-14-2026 11:00 AM
Location
PUB NCR
Primary Discipline of Presentation
Chemistry and Biochemistry
Abstract
Pseudomonas aeruginosa is a pathogen that is very adaptable, and can protect itself from situations such as host immune responses, or even treatments such as antibiotics. One of the genes that plays a role in the pathogenesis of P. aeruginosa is the ntrC gene, encoding a transcription factor. This gene is required for nitrogen utilization in low nitrogen conditions. Our goal is to define the regulon of the NtrC transcription factor in order to better understand its role in the biological processes of P. aeruginosa. To achieve this, my project focuses on the bioinformatic analysis of genomic data (RNA-sequencing and ChIP-exo sequencing) comparing wild type and ntrC mutant of the virulent P. aeruginosa PAK strain. The results from this study will identify the direct targets of NtrC and reveal its role in adaptability and pathogenesis of P. aeruginosa.
Recommended Citation
Gillespie, Jacob, "Role of NtrC in Pseudomonas aeruginosa" (2026). 2026 Symposium. 15.
https://dc.ewu.edu/srcw_2026/ps_2026/p1_2026/15
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Role of NtrC in Pseudomonas aeruginosa
PUB NCR
Pseudomonas aeruginosa is a pathogen that is very adaptable, and can protect itself from situations such as host immune responses, or even treatments such as antibiotics. One of the genes that plays a role in the pathogenesis of P. aeruginosa is the ntrC gene, encoding a transcription factor. This gene is required for nitrogen utilization in low nitrogen conditions. Our goal is to define the regulon of the NtrC transcription factor in order to better understand its role in the biological processes of P. aeruginosa. To achieve this, my project focuses on the bioinformatic analysis of genomic data (RNA-sequencing and ChIP-exo sequencing) comparing wild type and ntrC mutant of the virulent P. aeruginosa PAK strain. The results from this study will identify the direct targets of NtrC and reveal its role in adaptability and pathogenesis of P. aeruginosa.
