The effects of fructose and caffeine on novel object recognition in male Sprague Dawley rats
Faculty Mentor
David Daberkow
Document Type
Poster
Start Date
10-5-2023 11:15 AM
End Date
10-5-2023 1:00 PM
Location
PUB NCR
Department
Biology
Abstract
Introduction: Numerous studies have demonstrated that caffeine enhances cognitive abilities such as attention, alertness, and memory in both human and animal models. Conversely, excessive consumption of fructose can trigger insulin resistance, inflammation, and oxidative stress, thereby impairing cognitive function. This study aims to investigate the effects of caffeine and fructose on cognitive function in rats. Specifically, we examined whether short-term exposure to these substances enhances or diminishes cognitive functions.
Methods: Rats were divided into three groups and received either plain tap water (control), water containing fructose (10%), or water containing caffeine (0.3 g/L) for two weeks. Novel object recognition (NOR) was used to test cognitive function. The rats were given five minutes to explore a novel object, and the interactions were recorded on camera. Discrimination Indices (DI) and Preference Indices (PI) were calculated to compare novel and familiar object interaction time.
Results: Fructose-treated rats appeared to exhibit greater cognitive improvement compared to caffeine-treated rats and the control group, as demonstrated by the higher PI scores observed in this group. However, statistical analysis using ANOVA revealed no significant differences (p=0.217867) between the groups. Conclusions: These findings suggest that further research is needed to obtain more definitive results. Long-term treatment (8-12 weeks) and repeated testing using NOR may yield more conclusive data.
Recommended Citation
Escalante, Claudio; Gilchrist, Nicholas; and Farias, Amalia, "The effects of fructose and caffeine on novel object recognition in male Sprague Dawley rats" (2023). 2023 Symposium. 48.
https://dc.ewu.edu/srcw_2023/res_2023/p2_2023/48
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
The effects of fructose and caffeine on novel object recognition in male Sprague Dawley rats
PUB NCR
Introduction: Numerous studies have demonstrated that caffeine enhances cognitive abilities such as attention, alertness, and memory in both human and animal models. Conversely, excessive consumption of fructose can trigger insulin resistance, inflammation, and oxidative stress, thereby impairing cognitive function. This study aims to investigate the effects of caffeine and fructose on cognitive function in rats. Specifically, we examined whether short-term exposure to these substances enhances or diminishes cognitive functions.
Methods: Rats were divided into three groups and received either plain tap water (control), water containing fructose (10%), or water containing caffeine (0.3 g/L) for two weeks. Novel object recognition (NOR) was used to test cognitive function. The rats were given five minutes to explore a novel object, and the interactions were recorded on camera. Discrimination Indices (DI) and Preference Indices (PI) were calculated to compare novel and familiar object interaction time.
Results: Fructose-treated rats appeared to exhibit greater cognitive improvement compared to caffeine-treated rats and the control group, as demonstrated by the higher PI scores observed in this group. However, statistical analysis using ANOVA revealed no significant differences (p=0.217867) between the groups. Conclusions: These findings suggest that further research is needed to obtain more definitive results. Long-term treatment (8-12 weeks) and repeated testing using NOR may yield more conclusive data.
