Relationship between Sickle cell trait and effects of Sickle cell disease
Faculty Mentor
Judd Case
Document Type
Poster
Start Date
10-5-2023 11:15 AM
End Date
10-5-2023 1:00 PM
Location
PUB NCR
Department
Biology
Abstract
Sickle cell disease is the presence of two hemoglobin S alleles and results in sickle shaped red blood cells and other associated problems. Sickle cell trait only occurs in heterozygotes containing only one HbS allele and one normal allele (Hb). Individuals with sickle cell trait are usually asymptomatic. We aimed to assess if carriers of sickle cell trait are completely harmless from the effects of sickle cell disease. Individuals with sickle cell trait can develop sickled red blood cells through HbS polymerization. We found many different factors can contribute to sickling events occurring in individuals with sickle cell trait, such as intense physical activity and high elevations. Sickled red blood cells only carry a small portion of oxygen as normal red blood cells and because of their shape they can get stuck in the blood stream. Sickle cell trait and sickle cell disease have been known to cause acute renal failure. Sudden death syndrome can also occur in someone with the sickle cell trait. Awareness in both sickle cell disease and sickle cell trait can reduce misleading and unreliable information.
Recommended Citation
Brandt, Jodi and Case, Dr. Judd, "Relationship between Sickle cell trait and effects of Sickle cell disease" (2023). 2023 Symposium. 36.
https://dc.ewu.edu/srcw_2023/res_2023/p2_2023/36
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Relationship between Sickle cell trait and effects of Sickle cell disease
PUB NCR
Sickle cell disease is the presence of two hemoglobin S alleles and results in sickle shaped red blood cells and other associated problems. Sickle cell trait only occurs in heterozygotes containing only one HbS allele and one normal allele (Hb). Individuals with sickle cell trait are usually asymptomatic. We aimed to assess if carriers of sickle cell trait are completely harmless from the effects of sickle cell disease. Individuals with sickle cell trait can develop sickled red blood cells through HbS polymerization. We found many different factors can contribute to sickling events occurring in individuals with sickle cell trait, such as intense physical activity and high elevations. Sickled red blood cells only carry a small portion of oxygen as normal red blood cells and because of their shape they can get stuck in the blood stream. Sickle cell trait and sickle cell disease have been known to cause acute renal failure. Sudden death syndrome can also occur in someone with the sickle cell trait. Awareness in both sickle cell disease and sickle cell trait can reduce misleading and unreliable information.
