Influences of Multiple Myeloma on Osteoclastogenesis
Faculty Mentor
Jason Ashley
Presentation Type
Oral Presentation
Start Date
5-7-2025 10:50 AM
End Date
5-7-2025 11:10 AM
Location
PUB 317
Primary Discipline of Presentation
Biology
Abstract
Multiple myeloma is a cancer of antibody secreting B lymphocytes, also known as plasma cells. While both malignant and non-malignant plasma cells are home to the bone marrow, myeloma is often accompanied by osteodegenerative disease which is characterized by an imbalance of bone resorption and formation in favor of the former. Bone disease in multiple myeloma is driven by dysregulated signaling of myeloma cells and the increased abundance of these cells in the bone marrow. Osteoclasts are bone resorbing cells – formed from the fusion of macrophages – whose activity are putatively enhanced by the presence of multiple myeloma cells. Herein, using in vitro models, we investigate the influences of multiple myeloma on the differentiation of osteoclasts at 1) various temporal stages of osteoclastogenesis, 2) the spatial requirements of these effects, and 3) the underpinnings biological mechanisms at play. The results of this work will further elucidate the underlying biology of bone disease in multiple myeloma and will inform potential precision medicine strategies to ameliorate this disease sequelae.
Recommended Citation
Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M, Dimopoulos MA. Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Blood Cancer J. 2018 Jan 12;8(1):7. doi: 10.1038/s41408-017-0037-4. PMID: 29330358; PMCID: PMC5802524. Yaccoby S, Wezeman MJ, Henderson A, Cottler-Fox M, Yi Q, Barlogie B, Epstein J. Cancer and the microenvironment: myeloma-osteoclast interactions as a model. Cancer Res. 2004 Mar 15;64(6):2016-23. doi: 10.1158/0008-5472.can-03-1131. PMID: 15026338.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Influences of Multiple Myeloma on Osteoclastogenesis
PUB 317
Multiple myeloma is a cancer of antibody secreting B lymphocytes, also known as plasma cells. While both malignant and non-malignant plasma cells are home to the bone marrow, myeloma is often accompanied by osteodegenerative disease which is characterized by an imbalance of bone resorption and formation in favor of the former. Bone disease in multiple myeloma is driven by dysregulated signaling of myeloma cells and the increased abundance of these cells in the bone marrow. Osteoclasts are bone resorbing cells – formed from the fusion of macrophages – whose activity are putatively enhanced by the presence of multiple myeloma cells. Herein, using in vitro models, we investigate the influences of multiple myeloma on the differentiation of osteoclasts at 1) various temporal stages of osteoclastogenesis, 2) the spatial requirements of these effects, and 3) the underpinnings biological mechanisms at play. The results of this work will further elucidate the underlying biology of bone disease in multiple myeloma and will inform potential precision medicine strategies to ameliorate this disease sequelae.
